Genome Targeted Inhibitors of Retroviruses

Pandey, Virendra Nath

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI042520-05
• Application #: 6785435
• Study Section: AIDS and Related Research 8 (AARR)
• Program Officer: Gupta, Kailash C
• Project Start: 1999-04-01
• Project End: 2008-01-31
• Budget Start: 2004-02-01
• Budget End: 2005-01-31
• Support Year: 5
• Fiscal Year: 2004
• Total Cost: $388,750

Institution

• Name: University of Medicine & Dentistry of NJ
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 623946217
• City: Newark
• State: NJ
• Country: United States
• Zip Code: 07107

Publications

Das, Indrajit; Désiré, Jérôme; Manvar, Dinesh et al. (2012) A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription. J Med Chem 55:6021-32

Upadhyay, Alok K; Talele, Tanaji T; Pandey, Virendra N (2010) Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer. Mol Cell Biochem 338:19-33

Upadhyay, Alok; Pandey, Nootan; Mishra, Chaturbhuj A et al. (2010) A single deletion at position 134, 135, or 136 in the beta 7-beta 8 loop of the p51 subunit of HIV-1 RT disrupts the formation of heterodimeric enzyme. J Cell Biochem 109:598-605

Talele, Tanaji T; Upadhyay, Alok; Pandey, Virendra N (2009) Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains. Virol J 6:159

Pandey, Virendra N; Upadhyay, Alok; Chaubey, Binay (2009) Prospects for antisense peptide nucleic acid (PNA) therapies for HIV. Expert Opin Biol Ther 9:975-89

Tripathi, Snehlata; Chaubey, Binay; Barton, Beverly E et al. (2007) Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 genome. Virology 363:91-103