Abstract

The goal of this proposal is to understand the nature of transcription factor binding, apoptosis and the role of Nef and Nef-binding proteins in the avoidance of killing by MHC class I-restricted CTLs. The role of Nef in down regulating MHC class I expression will be assessed using techniques that allow characterization by flow cytometric analysis of events in primary and cultured cells with high-titered mutant or wild-type viruses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI042549-04
Application #
6328775
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Wassef, Nabila M
Project Start
1997-12-01
Project End
2002-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
4
Fiscal Year
2001
Total Cost
$277,304
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Qin, Xiao-Feng; An, Dong Sung; Chen, Irvin S Y et al. (2003) Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A 100:183-8
Pomerantz, Joel L; Denny, Elissa M; Baltimore, David (2002) CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J 21:5184-94
Sanjabi, S; Hoffmann, A; Liou, H C et al. (2000) Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc Natl Acad Sci U S A 97:12705-10
Collins, K L; Baltimore, D (1999) HIV's evasion of the cellular immune response. Immunol Rev 168:65-74
Pomerantz, J L; Baltimore, D (1999) NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J 18:6694-704
Jurgens, T M; Hufford, C D; Clark, A M (1992) The metabolism of muzigadial by microorganisms. Xenobiotica 22:569-77
Liu, S C; Oguntimein, B; Hufford, C D et al. (1990) 3-Methoxysampangine, a novel antifungal copyrine alkaloid from Cleistopholis patens. Antimicrob Agents Chemother 34:529-33
Hufford, C D; Liu, S C; Clark, A M (1988) Antifungal activity of Trillium grandiflorum constituents. J Nat Prod 51:94-8
Clark, A M; Watson, E S; Ashfaq, M K et al. (1987) In vivo efficacy of antifungal oxoaporphine alkaloids in experimental disseminated candidiasis. Pharm Res 4:495-8
Hufford, C D; Liu, S; Clark, A M et al. (1987) Anticandidal activity of eupolauridine and onychine, alkaloids from Cleistopholis patens. J Nat Prod 50:961-4

Showing the most recent 10 out of 11 publications