Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI042756-06
Application #
6764129
Study Section
Biochemistry Study Section (BIO)
Program Officer
Peters, Kent
Project Start
1998-02-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
6
Fiscal Year
2004
Total Cost
$226,500
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Brown, Daniel W; Schaab, Matthew R; Birmingham, William R et al. (2009) Evolution of the antibiotic resistance protein, FosA, is linked to a catalytically promiscuous progenitor. Biochemistry 48:1847-9
Rigsby, Rachel E; Brown, Daniel W; Dawson, Eric et al. (2007) A model for glutathione binding and activation in the fosfomycin resistance protein, FosA. Arch Biochem Biophys 464:277-83
Fillgrove, Kerry L; Pakhomova, Svetlana; Schaab, Matthew R et al. (2007) Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. Biochemistry 46:8110-20
Walsby, Charles J; Telser, Joshua; Rigsby, Rachel E et al. (2005) Enzyme control of small-molecule coordination in FosA as revealed by 31P pulsed ENDOR and ESE-EPR. J Am Chem Soc 127:8310-9
Rigsby, Rachel E; Rife, Chris L; Fillgrove, Kerry L et al. (2004) Phosphonoformate: a minimal transition state analogue inhibitor of the fosfomycin resistance protein, FosA. Biochemistry 43:13666-73
Pakhomova, Svetlana; Rife, Chris L; Armstrong, Richard N et al. (2004) Structure of fosfomycin resistance protein FosA from transposon Tn2921. Protein Sci 13:1260-5
Fillgrove, Kerry L; Pakhomova, Svetlana; Newcomer, Marcia E et al. (2003) Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. J Am Chem Soc 125:15730-1
Smoukov, Stoyan K; Telser, Joshua; Bernat, Bryan A et al. (2002) EPR study of substrate binding to the Mn(II) active site of the bacterial antibiotic resistance enzyme FosA: a better way to examine Mn(II). J Am Chem Soc 124:2318-26
Rife, Chris L; Pharris, Rachel E; Newcomer, Marcia E et al. (2002) Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+). J Am Chem Soc 124:11001-3
Cao, M; Bernat, B A; Wang, Z et al. (2001) FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis. J Bacteriol 183:2380-3

Showing the most recent 10 out of 13 publications