Immune Responses to Autoantigens in the Induction of Sle

Fu, Shu Man

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI043248-05
• Application #: 6373850
• Study Section: Special Emphasis Panel (ZRG2-EI (03))
• Program Officer: Johnson, David R
• Project Start: 1997-09-30
• Project End: 2003-08-31
• Budget Start: 2001-09-01
• Budget End: 2003-08-31
• Support Year: 5
• Fiscal Year: 2001
• Total Cost: $242,070

Institution

• Name: University of Virginia
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 001910777
• City: Charlottesville
• State: VA
• Country: United States
• Zip Code: 22904

Publications

Jiang, Chao; Deshmukh, Umesh S; Gaskin, Felicia et al. (2010) Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens. J Immunol 184:1085-91

Deshmukh, Umesh S; Bagavant, Harini; Sim, Davis et al. (2007) A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading. J Immunol 178:2565-71

Rose Jr, C Edward; Sung, Sung-Sang J; Fu, Shu Man (2003) Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung. Microcirculation 10:273-88