Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI043846-07
Application #
6760996
Study Section
AIDS and Related Research 8 (AARR)
Program Officer
Laughon, Barbara E
Project Start
1998-08-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
7
Fiscal Year
2004
Total Cost
$408,750
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Lun, Shichun; Miranda, David; Kubler, Andre et al. (2014) Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to ?-lactams. MBio 5:e01767-14
Olaleye, Omonike; Raghunand, Tirumalai R; Bhat, Shridhar et al. (2011) Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis (Edinb) 91 Suppl 1:S61-5
Olaleye, Omonike; Raghunand, Tirumalai R; Bhat, Shridhar et al. (2010) Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets. Chem Biol 17:86-97
Parrish, Nicole M; Ko, Chiew G; Dick, James D (2009) Activity of DSA against anaerobically adapted Mycobacterium bovis BCG in vitro. Tuberculosis (Edinb) 89:325-7
Ahmad, Zahoor; Klinkenberg, Lee G; Pinn, Michael L et al. (2009) Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis 200:1136-43
Be, Nicholas A; Lamichhane, Gyanu; Grosset, Jacques et al. (2008) Murine model to study the invasion and survival of Mycobacterium tuberculosis in the central nervous system. J Infect Dis 198:1520-8
Klinkenberg, Lee G; Sutherland, Lesley A; Bishai, William R et al. (2008) Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency. J Infect Dis 198:275-83
Lee, Jong-Hee; Karakousis, Petros C; Bishai, William R (2008) Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network. J Bacteriol 190:699-707
Nuermberger, Eric; Tyagi, Sandeep; Tasneen, Rokeya et al. (2008) Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis. Antimicrob Agents Chemother 52:1522-4
Abdul-Majid, Khairul-Bariah; Ly, Lan H; Converse, Paul J et al. (2008) Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice. BMC Microbiol 8:151

Showing the most recent 10 out of 50 publications