Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI045406-03
Application #
6349913
Study Section
Special Emphasis Panel (ZRG1-AARR-2 (01))
Program Officer
Plaeger, Susan F
Project Start
1999-02-15
Project End
2004-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
3
Fiscal Year
2001
Total Cost
$410,910
Indirect Cost
Name
Immune Disease Institute, Inc.
Department
Type
DUNS #
115524410
City
Boston
State
MA
Country
United States
Zip Code
02115
Lieberman, Judy (2004) Tracking the killers: how should we measure CD8 T cells in HIV infection? AIDS 18:1489-93
Lange, Christoph G; Xu, Zhan; Patterson, Bruce K et al. (2004) Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS 18:605-13
Song, Erwei; Lee, Sang-Kyung; Wang, Jie et al. (2003) RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9:347-51
Zhang, Dong; Shankar, Premlata; Xu, Zhan et al. (2003) Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood 101:226-35
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Chen, G; Shankar, P; Lange, C et al. (2001) CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood 98:156-64
Lieberman, J; Shankar, P; Manjunath, N et al. (2001) Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98:1667-77
Manjunath, N; Shankar, P; Wan, J et al. (2001) Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest 108:871-8
Trimble, L A; Kam, L W; Friedman, R S et al. (2000) CD3zeta and CD28 down-modulation on CD8 T cells during viral infection. Blood 96:1021-9
Trimble, L A; Shankar, P; Patterson, M et al. (2000) Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation. J Virol 74:7320-30

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