Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052351-02
Application #
6699981
Study Section
Virology Study Section (VR)
Program Officer
Nabavi, Nasrin N
Project Start
2003-02-01
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
2
Fiscal Year
2004
Total Cost
$375,400
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Hosking, Martin P; Flynn, Claudia T; Whitton, J Lindsay (2014) Antigen-specific naive CD8+ T cells produce a single pulse of IFN-? in vivo within hours of infection, but without antiviral effect. J Immunol 193:1873-85
Hosking, Martin P; Flynn, Claudia T; Botten, Jason et al. (2013) CD8+ memory T cells appear exhausted within hours of acute virus infection. J Immunol 191:4211-22
Misumi, Ichiro; Alirezaei, Mehrdad; Eam, Boreth et al. (2013) Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. J Immunol 191:5655-68
Alirezaei, Mehrdad; Kemball, Christopher C; Whitton, J Lindsay (2011) Autophagy, inflammation and neurodegenerative disease. Eur J Neurosci 33:197-204
Whitmire, Jason K; Eam, Boreth; Whitton, J Lindsay (2009) Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. Eur J Immunol 39:1494-504
Whitmire, Jason K; Benning, Nicola; Eam, Boreth et al. (2008) Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. J Immunol 180:6777-85
Liu, Fei; Whitton, J Lindsay (2005) Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J Immunol 174:5936-40