Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052459-08
Application #
6692174
Study Section
Metabolism Study Section (MET)
Program Officer
Mallia, Conrad M
Project Start
1995-08-10
Project End
2005-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
8
Fiscal Year
2004
Total Cost
$272,022
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Srivastava, Shekhar; Cai, Xinjiang; Li, Zhai et al. (2012) Phosphatidylinositol-3-kinase C2? and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells. Mol Cell Biol 32:3132-9
Cai, Xinjiang; Srivastava, Shekhar; Sun, Yi et al. (2011) Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2?. Proc Natl Acad Sci U S A 108:20072-7
Zhdanova, Olga; Srivastava, Shekhar; Di, Lie et al. (2011) The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int 80:719-30
Di, Lie; Srivastava, Shekhar; Zhdanova, Olga et al. (2010) Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis. Proc Natl Acad Sci U S A 107:1541-6
Di, Lie; Srivastava, Shekhar; Zhdanova, Olga et al. (2010) Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation. J Biol Chem 285:38765-71
Srivastava, Shekhar; Di, Lie; Zhdanova, Olga et al. (2009) The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Mol Biol Cell 20:3783-91
Srivastava, Shekhar; Zhdanova, Olga; Di, Lie et al. (2008) Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. Proc Natl Acad Sci U S A 105:14442-6