Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI053056-02
Application #
6686028
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Esch, Thomas R
Project Start
2002-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$355,500
Indirect Cost
Name
Dartmouth College
Department
Pathology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Milks, Michael W; Cripps, James G; Lin, Heping et al. (2009) The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis. Liver Int 29:1307-15
Robinson, Richard T; Wang, Jing; Cripps, James G et al. (2009) End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas. J Immunol 182:3278-84
Park, Il-Kyoo; Letterio, John J; Gorham, James D (2007) TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent. Mol Immunol 44:3283-90
Robinson, Richard T; Gorham, James D (2007) TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the periphery. J Immunol 179:71-9
Robinson, Richard T; French, Margaret A; Kitzmiller, Tamar J et al. (2006) Restriction of the CD4+ T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout mice. Lab Invest 86:815-28
Lin, Jack T; Martin, Stacey L; Xia, Luxi et al. (2005) TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J Immunol 174:5950-8
Park, Il-Kyoo; Shultz, Leonard D; Letterio, John J et al. (2005) TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol 175:5666-74
Gorham, James D (2005) Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease. Transfusion 45:51S-59S
Lin, Jack T; Kitzmiller, Tamar J; Cates, Justin M M et al. (2005) MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury. Lab Invest 85:550-61
Rudner, Lynnie A; Lin, Jack T; Park, Il-Kyoo et al. (2003) Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells. J Immunol 170:4785-92

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