Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI053174-02
Application #
6756599
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Berard, Diana S
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$324,000
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Settembre, Ethan C; Chen, James Z; Dormitzer, Philip R et al. (2011) Atomic model of an infectious rotavirus particle. EMBO J 30:408-16
Aoki, Scott T; Trask, Shane D; Coulson, Barbara S et al. (2011) Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry. J Virol 85:10509-17
Kim, Irene S; Trask, Shane D; Babyonyshev, Marina et al. (2010) Effect of mutations in VP5 hydrophobic loops on rotavirus cell entry. J Virol 84:6200-7
Trask, Shane D; Kim, Irene S; Harrison, Stephen C et al. (2010) A rotavirus spike protein conformational intermediate binds lipid bilayers. J Virol 84:1764-70
Chen, James Z; Settembre, Ethan C; Aoki, Scott T et al. (2009) Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A 106:10644-8
Yoder, Joshua D; Trask, Shane D; Vo, T Phuoc et al. (2009) VP5* rearranges when rotavirus uncoats. J Virol 83:11372-7
Zhang, Xing; Settembre, Ethan; Xu, Chen et al. (2008) Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A 105:1867-72
Yoder, Joshua D; Dormitzer, Philip R (2006) Alternative intermolecular contacts underlie the rotavirus VP5* two- to three-fold rearrangement. EMBO J 25:1559-68
Monnier, Nilah; Higo-Moriguchi, Kyoko; Sun, Zhen-Yu J et al. (2006) High-resolution molecular and antigen structure of the VP8* core of a sialic acid-independent human rotavirus strain. J Virol 80:1513-23
Trask, Shane D; Dormitzer, Philip R (2006) Assembly of highly infectious rotavirus particles recoated with recombinant outer capsid proteins. J Virol 80:11293-304

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