Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI056351-02
Application #
6769373
Study Section
Special Emphasis Panel (ZRG1-VACC (02))
Program Officer
Berard, Diana S
Project Start
2003-07-01
Project End
2007-06-30
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$384,133
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lindesmith, Lisa C; Mallory, Michael L; Jones, Taylor A et al. (2017) Impact of Pre-exposure History and Host Genetics on Antibody Avidity Following Norovirus Vaccination. J Infect Dis 215:984-991
Lindesmith, Lisa C; Beltramello, Martina; Swanstrom, Jesica et al. (2015) Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses. Open Forum Infect Dis 2:ofv084
Lindesmith, Lisa C; Ferris, Martin T; Mullan, Clancy W et al. (2015) Broad blockade antibody responses in human volunteers after immunization with a multivalent norovirus VLP candidate vaccine: immunological analyses from a phase I clinical trial. PLoS Med 12:e1001807
Lindesmith, Lisa C; Donaldson, Eric F; Beltramello, Martina et al. (2014) Particle conformation regulates antibody access to a conserved GII.4 norovirus blockade epitope. J Virol 88:8826-42
Debbink, Kari; Lindesmith, Lisa C; Baric, Ralph S (2014) The state of norovirus vaccines. Clin Infect Dis 58:1746-52
Swanstrom, Jesica; Lindesmith, Lisa C; Donaldson, Eric F et al. (2014) Characterization of blockade antibody responses in GII.2.1976 Snow Mountain virus-infected subjects. J Virol 88:829-37
Vega, Everardo; Donaldson, Eric; Huynh, Jeremy et al. (2014) RNA populations in immunocompromised patients as reservoirs for novel norovirus variants. J Virol 88:14184-96
Debbink, Kari; Lindesmith, Lisa C; Donaldson, Eric F et al. (2014) Chimeric GII.4 norovirus virus-like-particle-based vaccines induce broadly blocking immune responses. J Virol 88:7256-66
Debbink, Kari; Lindesmith, Lisa C; Ferris, Martin T et al. (2014) Within-host evolution results in antigenically distinct GII.4 noroviruses. J Virol 88:7244-55
Kirby, A E; Shi, J; Montes, J et al. (2014) Disease course and viral shedding in experimental Norwalk virus and Snow Mountain virus infection. J Med Virol 86:2055-64

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