Abstract

Public Health Relevance

Despite significant improvement in short-term survival of organ transplants, attrition of transplanted organs over time remains a significant clinical problem. Identifying the mechanisms by which the immune system recognizes transplanted organs as foreign and continues to reject them could lead to novel therapies that enhance long-term graft and patient survival after transplantation. !

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI099465-01A1
Application #
8435594
Study Section
Transplantation, Tolerance, and Tumor Immunology (TTT)
Program Officer
Rice, Jeffrey S
Project Start
2012-09-27
Project End
2017-08-31
Budget Start
2012-09-27
Budget End
2013-08-31
Support Year
1
Fiscal Year
2012
Total Cost
$379,675
Indirect Cost
$129,675

  Institution

Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Lakkis, F G; Li, X C (2018) Innate allorecognition by monocytic cells and its role in graft rejection. Am J Transplant 18:289-292
Dai, Hehua; Friday, Andrew J; Abou-Daya, Khodor I et al. (2017) Donor SIRP? polymorphism modulates the innate immune response to allogeneic grafts. Sci Immunol 2:
Zhuang, Quan; Liu, Quan; Divito, Sherrie J et al. (2016) Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun 7:12623
Tieu, Roger; Lakkis, Fadi G; Oberbarnscheidt, Martin H (2016) Getting Down and Dirty: Germ-Exposed Laboratory Mice as a Model of the Adult Human Immune System. Transplantation 100:2490-2491
Alegre, Maria-Luisa; Lakkis, Fadi G; Morelli, Adrian E (2016) Antigen Presentation in Transplantation. Trends Immunol 37:831-843
Yatim, Karim M; Lakkis, Fadi G (2015) A brief journey through the immune system. Clin J Am Soc Nephrol 10:1274-81
Zhuang, Quan; Lakkis, Fadi G (2015) Dendritic cells and innate immunity in kidney transplantation. Kidney Int 87:712-8
Oberbarnscheidt, Martin H; Zeng, Qiang; Li, Qi et al. (2014) Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 124:3579-89
Oberbarnscheidt, Martin H; Lakkis, Fadi G (2014) Innate allorecognition. Immunol Rev 258:145-9