Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR015781-16S1
Application #
3154841
Study Section
Physiology Study Section (PHY)
Project Start
1975-01-01
Project End
1989-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722

  Publications

Jurutka, P W; Remus, L S; Whitfield, G K et al. (2000) The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol 14:401-20
Thompson, P D; Jurutka, P W; Haussler, C A et al. (1998) Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions. J Biol Chem 273:8483-91
Haussler, M R; Haussler, C A; Jurutka, P W et al. (1997) The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol 154 Suppl:S57-73
Jurutka, P W; Hsieh, J C; Remus, L S et al. (1997) Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription facto J Biol Chem 272:14592-9
Whitfield, G K; Selznick, S H; Haussler, C A et al. (1996) Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Mol Endocrinol 10:1617-31
Jurutka, P W; Hsieh, J C; Nakajima, S et al. (1996) Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation. Proc Natl Acad Sci U S A 93:3519-24
Nakajima, S; Hsieh, J C; Jurutka, P et al. (1996) Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor. J Biol Chem 271:5143-9
Ray, R; Swamy, N; MacDonald, P N et al. (1996) Affinity labeling of the 1 alpha,25-dihydroxyvitamin D3 receptor. J Biol Chem 271:2012-7
Hsieh, J C; Jurutka, P W; Selznick, S H et al. (1995) The T-box near the zinc fingers of the human vitamin D receptor is required for heterodimeric DNA binding and transactivation. Biochem Biophys Res Commun 215:1-7
Haussler, M R; Jurutka, P W; Hsieh, J C et al. (1995) New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone 17:33S-38S

Showing the most recent 10 out of 38 publications