Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR018983-20
Application #
2078406
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1979-01-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Carolina at Columbia
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208
Wuthier, Roy E; Lipscomb, Guy F (2011) Matrix vesicles: structure, composition, formation and function in calcification. Front Biosci (Landmark Ed) 16:2812-902
Wu, Licia N Y; Genge, Brian R; Wuthier, Roy E (2008) Analysis and molecular modeling of the formation, structure, and activity of the phosphatidylserine-calcium-phosphate complex associated with biomineralization. J Biol Chem 283:3827-38
Genge, Brian R; Wu, Licia N Y; Wuthier, Roy E (2008) Mineralization of annexin-5-containing lipid-calcium-phosphate complexes: modulation by varying lipid composition and incubation with cartilage collagens. J Biol Chem 283:9737-48
Genge, Brian R; Wu, Licia N Y; Wuthier, Roy E (2007) In vitro modeling of matrix vesicle nucleation: synergistic stimulation of mineral formation by annexin A5 and phosphatidylserine. J Biol Chem 282:26035-45
Genge, Brian R; Wu, Licia N Y; Wuthier, Roy E (2007) Kinetic analysis of mineral formation during in vitro modeling of matrix vesicle mineralization: effect of annexin A5, phosphatidylserine, and type II collagen. Anal Biochem 367:159-66
Wu, L N Y; Genge, B R; Ishikawa, Y et al. (2006) Effects of 24R,25- and 1alpha,25-dihydroxyvitamin D3 on mineralizing growth plate chondrocytes. J Cell Biochem 98:309-34
Wu, Licia N Y; Ishikawa, Yoshinori; Genge, Brian R et al. (2005) Chondrocytes isolated from tibial dyschondroplasia lesions and articular cartilage revert to a growth plate-like phenotype when cultured in vitro. J Cell Physiol 202:167-77
Sauer, Glenn R; Smith, Della M; Cahalane, Matthew et al. (2003) Intracellular zinc fluxes associated with apoptosis in growth plate chondrocytes. J Cell Biochem 88:954-69
Genge, Brian R; Wu, Licia N Y; Wuthier, Roy E (2003) Separation and quantification of chicken and bovine growth plate cartilage matrix vesicle lipids by high-performance liquid chromatography using evaporative light scattering detection. Anal Biochem 322:104-15
Wu, Licia N Y; Sauer, Glenn R; Genge, Brian R et al. (2003) Effects of analogues of inorganic phosphate and sodium ion on mineralization of matrix vesicles isolated from growth plate cartilage of normal rapidly growing chickens. J Inorg Biochem 94:221-35

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