Abstract

This project is designed to investigate the functional relationship between the loading characteristics of total joint components and remodeling of the supporting trabecular bone. The specific objective is to identify the optimum stress parameters which promote positive trabecular bone remodeling. Utilizing implantable load transmitting devices, the dynamic response of canine metaphyseal trabecular bone to controlled loading, stimuli will be measured. The phases of the study will include: 1. Fabrication and calibration of the implanted load delivery system; 2. Assessment and documentation of all control variables and measurements; 3. Measurement and analysis of trabecular bone remodeling responses to experimentally controlled stress fields. The experimental variables will be measured using the following techniques: computed axial tomography, histologic section and fluorescence, mechanical materials testing, ash weight determination, and three dimensional micro computed tomography.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR031793-03
Application #
3156088
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1983-12-01
Project End
1988-11-30
Budget Start
1985-12-15
Budget End
1986-11-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Moalli, M R; Caldwell, N J; Patil, P V et al. (2000) An in vivo model for investigations of mechanical signal transduction in trabecular bone. J Bone Miner Res 15:1346-53
Guldberg, R E; Hollister, S J; Charras, G T (1998) The accuracy of digital image-based finite element models. J Biomech Eng 120:289-95
Guldberg, R E; Caldwell, N J; Guo, X E et al. (1997) Mechanical stimulation of tissue repair in the hydraulic bone chamber. J Bone Miner Res 12:1295-302
Guldberg, R E; Richards, M; Caldwell, N J et al. (1997) Trabecular bone adaptation to variations in porous-coated implant topology. J Biomech 30:147-53
Hollister, S J; Guldberg, R E; Kuelske, C L et al. (1996) Relative effects of wound healing and mechanical stimulus on early bone response to porous-coated implants. J Orthop Res 14:654-62
Choi, K; Goldstein, S A (1992) A comparison of the fatigue behavior of human trabecular and cortical bone tissue. J Biomech 25:1371-81
Goldstein, S A; Matthews, L S; Kuhn, J L et al. (1991) Trabecular bone remodeling: an experimental model. J Biomech 24 Suppl 1:135-50
Hollister, S J; Fyhrie, D P; Jepsen, K J et al. (1991) Application of homogenization theory to the study of trabecular bone mechanics. J Biomech 24:825-39
Choi, K; Kuhn, J L; Ciarelli, M J et al. (1990) The elastic moduli of human subchondral, trabecular, and cortical bone tissue and the size-dependency of cortical bone modulus. J Biomech 23:1103-13
Kuhn, J L; Goulet, R W; Pappas, M et al. (1990) Morphometric and anisotropic symmetries of the canine distal femur. J Orthop Res 8:776-80

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