Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR034358-09
Application #
3156809
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1984-09-01
Project End
1992-08-31
Budget Start
1991-09-03
Budget End
1992-08-31
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Burlingame, R W; Rubin, R L; Rosenberg, A M (1993) Autoantibodies to chromatin components in juvenile rheumatoid arthritis. Arthritis Rheum 36:836-41
Rubin, R L; Bell, S A; Burlingame, R W (1992) Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex. J Clin Invest 90:165-73
Rubin, R L (1992) Autoantibody specificity in drug-induced lupus and neutrophil-mediated metabolism of lupus-inducing drugs. Clin Biochem 25:223-34
Burlingame, R W; Rubin, R L (1992) Anti-histone autoantibodies recognize centromeric heterochromatin in metaphase chromosomes and hidden epitopes in interphase cells. Hum Antibodies Hybridomas 3:40-7
Bell, S A; Hobbs, M V; Rubin, R L (1992) Isotype-restricted hyperimmunity in a murine model of the toxic oil syndrome. J Immunol 148:3369-76
Rubin, R L; Burlingame, R W (1991) Drug-induced autoimmunity: a disorder at the interface between metabolism and immunity. Biochem Soc Trans 19:153-9
Burlingame, R W; Rubin, R L (1991) Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin. J Clin Invest 88:680-90
Roberts, D E; Peebles, C; Curd, J G et al. (1991) Autoantibodies to native myeloperoxidase in patients with pulmonary hemorrhage and acute renal failure. J Clin Immunol 11:389-97
Rubin, R L; Tang, F L; Tsay, G et al. (1990) Pseudoautoimmunity in normal mice: anti-histone antibodies elicited by immunization versus induction during graft-versus-host reaction. Clin Immunol Immunopathol 54:320-32
Burlingame, R W; Rubin, R L (1990) Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J Immunol Methods 134:187-99

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