Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR038349-02
Application #
3158508
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1987-05-01
Project End
1992-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Hauschka, P V; Damoulis, P D (1998) Functions of nitric oxide in bone. Biochem Soc Trans 26:39-44
Damoulis, P D; Hauschka, P V (1997) Nitric oxide acts in conjunction with proinflammatory cytokines to promote cell death in osteoblasts. J Bone Miner Res 12:412-22
Asahina, I; Sampath, T K; Hauschka, P V (1996) Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 222:38-47
Hunter, G K; Hauschka, P V; Poole, A R et al. (1996) Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem J 317 ( Pt 1):59-64
Neugebauer, B M; Moore, M A; Broess, M et al. (1995) Characterization of structural sequences in the chicken osteocalcin gene: expression of osteocalcin by maturing osteoblasts and by hypertrophic chondrocytes in vitro. J Bone Miner Res 10:157-63
Damoulis, P D; Hauschka, P V (1994) Cytokines induce nitric oxide production in mouse osteoblasts. Biochem Biophys Res Commun 201:924-31
Maliakal, J C; Asahina, I; Hauschka, P V et al. (1994) Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells. Growth Factors 11:227-34
Asahina, I; Sampath, T K; Nishimura, I et al. (1993) Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 123:921-33
Taichman, R S; Hauschka, P V (1992) Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. Inflammation 16:587-601
Spampata, R; Werther, J R; Hauschka, P V (1992) Accelerated endochondral osteoinduction in the absence of bone matrix particles in a rat model system. J Oral Maxillofac Surg 50:140-51;discussion 151-2

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