Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR038796-01
Application #
3158801
Study Section
Physiology Study Section (PHY)
Project Start
1986-09-01
Project End
1988-03-31
Budget Start
1986-09-01
Budget End
1987-03-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Li, Y; Llewellyn, L; Moczydlowski, E (1993) Biochemical and immunochemical comparison of saxiphilin and transferrin, two structurally related plasma proteins from Rana catesbeiana. Mol Pharmacol 44:742-8
Ravindran, A; Kwiecinski, H; Alvarez, O et al. (1992) Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore. Biophys J 61:494-508
Moczydlowski, E (1992) Analysis of drug action at single-channel level. Methods Enzymol 207:791-806
Schild, L; Ravindran, A; Moczydlowski, E (1991) Zn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics. J Gen Physiol 97:117-42
Ravindran, A; Schild, L; Moczydlowski, E (1991) Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels. J Gen Physiol 97:89-115
Schild, L; Moczydlowski, E (1991) Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site. Biophys J 59:523-37
Li, Y; Moczydlowski, E (1991) Purification and partial sequencing of saxiphilin, a saxitoxin-binding protein from the bullfrog, reveals homology to transferrin. J Biol Chem 266:15481-7
Mahar, J; Lukacs, G L; Li, Y et al. (1991) Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana). Toxicon 29:53-71
Lucchesi, K; Moczydlowski, E (1990) Subconductance behavior in a maxi Ca2(+)-activated K+ channel induced by dendrotoxin-I. Neuron 4:141-8
Lucchesi, K; Ravindran, A; Young, H et al. (1989) Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels. J Membr Biol 109:269-81

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