Organization of Autoantibody Vh Genes

Barrett, Kathleen J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 7R01AR038821-07
• Application #: 3158818
• Study Section: Allergy and Immunology Study Section (ALY)
• Project Start: 1986-09-01
• Project End: 1993-11-30
• Budget Start: 1992-06-20
• Budget End: 1993-11-30
• Support Year: 7
• Fiscal Year: 1991

Institution

• Name: Boston University
• Type: Schools of Medicine
• DUNS #: 604483045
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02118

Publications

Gangemi, R M; Singh, A K; Barrett, K J (1993) Independently derived IgG anti-DNA autoantibodies from two lupus-prone mouse strains express a VH gene that is not present in most murine strains. J Immunol 151:4660-71

Foster, M H; MacDonald, M; Barrett, K J et al. (1991) VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies. J Immunol 147:1504-11

Guillaume, T; Rubinstein, D B; Young, F et al. (1990) Individual VH genes detected with oligonucleotide probes from the complementarity-determining regions. J Immunol 145:1934-45

Souroujon, M C; Rubinstein, D B; Schwartz, R S et al. (1989) Polymorphisms in human H chain V region genes from the VHIII gene family. J Immunol 143:706-11

Barrett, K J (1989) Anti-DNA antibodies, autoimmunity and the immunoglobulin repertoire. Int Rev Immunol 5:43-78

Trepicchio Jr, W; Maruya, A; Barrett, K J (1987) The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus. J Immunol 139:3139-45