Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR039190-05
Application #
3159169
Study Section
Pathology B Study Section (PTHB)
Project Start
1988-07-01
Project End
1997-04-30
Budget Start
1993-02-08
Budget End
1993-04-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Goruppi, Sandro; Jo, Seung-Hee; Laszlo, Csaba et al. (2018) Autophagy Controls CSL/RBPJ? Stability through a p62/SQSTM1-Dependent Mechanism. Cell Rep 24:3108-3114.e4
Al Labban, Dania; Jo, Seung-Hee; Ostano, Paola et al. (2018) Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B. J Clin Invest 128:2581-2599
Ă–zdemir, Berna C; Dotto, Gian-Paolo (2017) Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin? Trends Cancer 3:181-197
Goruppi, Sandro; Procopio, Maria-Giuseppina; Jo, Seunghee et al. (2017) The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. Cell Rep 20:2468-2479
Kim, Dong Eun; Procopio, Maria-Giuseppina; Ghosh, Soumitra et al. (2017) Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation. J Exp Med 214:2349-2368
Dotto, G Paolo; Rustgi, Anil K (2016) Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. Cancer Cell 29:622-637
Lefort, Karine; Ostano, Paola; Mello-Grand, Maurizia et al. (2016) Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer. Oncotarget 7:48011-48026
Jo, Seung-Hee; Kim, Dong Eun; Clocchiatti, Andrea et al. (2016) PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation. Oncotarget 7:58717-58727
Menietti, Elena; Xu, Xiaoying; Ostano, Paola et al. (2016) Negative control of CSL gene transcription by stress/DNA damage response and p53. Cell Cycle 15:1767-78
Procopio, Maria-Giuseppina; Laszlo, Csaba; Al Labban, Dania et al. (2015) Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. Nat Cell Biol 17:1193-204

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