Abstract

This revised grant is submitted in response to a request for proposals on clinical and epidemiologic research on minority populations of the U.S. and studies the effect of social, nutritional and environmental factors on disease activity among low-income American Blacks and Whites with Systemic Lupus Erythematosus (SLE). Nearly all studies examining the epidemiology of SLE have observed higher morbidity and mortality for black patients. Lower socioeconomic status is believed to explain this discrepancy, in part. Lower socioeconomic status is associated with factors such as diminished access to health care, inadequate knowledge of disease, less availability of social supports, etc. Many of these are amenable to public health and social policy strategies to improve health status in high-risk populations. A multicentered cross-sectional study is proposed. The study will confirm previous observations on the discrepant morbidity of black patients and identify potentially modifiable factors of public health importance which affect disease activity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR039921-01A1
Application #
3160164
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1991-02-01
Project End
1994-01-31
Budget Start
1991-02-01
Budget End
1992-01-31
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Bae, S C; Hashimoto, H; Karlson, E W et al. (2001) Variable effects of social support by race, economic status, and disease activity in systemic lupus erythematosus. J Rheumatol 28:1245-51
Rivest, C; Lew, R A; Welsing, P M et al. (2000) Association between clinical factors, socioeconomic status, and organ damage in recent onset systemic lupus erythematosus. J Rheumatol 27:680-4
Breitbach, S A; Alexander, R W; Daltroy, L H et al. (1998) Determinants of cognitive performance in systemic lupus erythematosus. J Clin Exp Neuropsychol 20:157-66
Wluka, A E; Liang, M H; Partridge, A J et al. (1997) Assessment of systemic lupus erythematosus disease activity by medical record review compared with direct standardized evaluation. Arthritis Rheum 40:57-61
Karlson, E W; Daltroy, L H; Lew, R A et al. (1997) The relationship of socioeconomic status, race, and modifiable risk factors to outcomes in patients with systemic lupus erythematosus. Arthritis Rheum 40:47-56
Grosflam, J M; Wright, E A; Cleary, P D et al. (1995) Predictors of blood loss during total hip replacement surgery. Arthritis Care Res 8:167-73
Karlson, E W; Daltroy, L H; Lew, R A et al. (1995) The independence and stability of socioeconomic predictors of morbidity in systemic lupus erythematosus. Arthritis Rheum 38:267-73
Katz, J N; Gelberman, R H; Wright, E A et al. (1994) A preliminary scoring system for assessing the outcome of carpal tunnel release. J Hand Surg Am 19:531-8
Katz, J N; Wright, E A; Guadagnoli, E et al. (1994) Differences between men and women undergoing major orthopedic surgery for degenerative arthritis. Arthritis Rheum 37:687-94
Stucki, G; Johannesson, M; Liang, M H (1994) Is misoprostol cost-effective in the prevention of nonsteroidal anti-inflammatory drug-induced gastropathy in patients with chronic arthritis? A review of conflicting economic evaluations. Arch Intern Med 154:2020-5

Showing the most recent 10 out of 13 publications