Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR039998-05S1
Application #
3160246
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1989-06-20
Project End
1995-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
039318308
City
Providence
State
RI
Country
United States
Zip Code
02906
Perrone, C E; Fenwick-Smith, D; Vandenburgh, H H (1995) Collagen and stretch modulate autocrine secretion of insulin-like growth factor-1 and insulin-like growth factor binding proteins from differentiated skeletal muscle cells. J Biol Chem 270:2099-106
Vandenburgh, H H; Shansky, J; Solerssi, R et al. (1995) Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. J Cell Physiol 163:285-94
Chromiak, J A; Vandenburgh, H H (1994) Mechanical stimulation of skeletal muscle cells mitigates glucocorticoid-induced decreases in prostaglandin production and prostaglandin synthase activity. J Cell Physiol 159:407-14
Vandenburgh, H H; Shansky, J; Karlisch, P et al. (1993) Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation. J Cell Physiol 155:63-71
Vandenburgh, H H (1992) Mechanical forces and their second messengers in stimulating cell growth in vitro. Am J Physiol 262:R350-5
Chromiak, J A; Vandenburgh, H H (1992) Glucocorticoid-induced skeletal muscle atrophy in vitro is attenuated by mechanical stimulation. Am J Physiol 262:C1471-7
Vandenburgh, H H; Karlisch, P; Shansky, J et al. (1991) Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture. Am J Physiol 260:C475-84
Vandenburgh, H H; Swasdison, S; Karlisch, P (1991) Computer-aided mechanogenesis of skeletal muscle organs from single cells in vitro. FASEB J 5:2860-7
Vandenburgh, H H; Hatfaludy, S; Karlisch, P et al. (1991) Mechanically induced alterations in cultured skeletal muscle growth. J Biomech 24 Suppl 1:91-9
Samuel, J L; Vandenburgh, H H (1990) Mechanically induced orientation of adult rat cardiac myocytes in vitro. In Vitro Cell Dev Biol 26:905-14

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