Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR040240-06A2
Application #
2079926
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1989-12-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Jarnik, Michal; de Viragh, Pierre A; Scharer, Elisabeth et al. (2002) Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system. J Invest Dermatol 118:102-9
Koch, P J; de Viragh, P A; Scharer, E et al. (2000) Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol 151:389-400
Suga, Y; Jarnik, M; Attar, P S et al. (2000) Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. J Cell Biol 151:401-12
DiSepio, D; Bickenbach, J R; Longley, M A et al. (1999) Characterization of loricrin regulation in vitro and in transgenic mice. Differentiation 64:225-35
Attar, P S; Wertz, P W; McArthur, M et al. (1997) Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function. Mol Endocrinol 11:792-800
Bickenbach, J R; Greer, J M; Bundman, D S et al. (1995) Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol 104:405-10
DiSepio, D; Jones, A; Longley, M A et al. (1995) The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. J Biol Chem 270:10792-9
Imakado, S; Bickenbach, J R; Bundman, D S et al. (1995) Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes Dev 9:317-29
Rothnagel, J A; Longley, M A; Bundman, D S et al. (1994) Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3. Genomics 23:450-6
Greenhalgh, D A; Rothnagel, J A; Roop, D R (1994) Epidermis: an attractive target tissue for gene therapy. J Invest Dermatol 103:63S-69S

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