Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR041331-03
Application #
2080619
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1994-03-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Helen Hayes Hospital
Department
Type
DUNS #
157119244
City
Menands
State
NY
Country
United States
Zip Code
12204
Bromme, N C; Wex, T; Wex, H et al. (2000) Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. Biochem Biophys Res Commun 271:474-80
Wex, T; Levy, B; Wex, H et al. (2000) Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases. Adv Exp Med Biol 477:271-80
Li, Z; Hou, W S; Bromme, D (2000) Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates. Biochemistry 39:529-36
Xia, L; Kilb, J; Wex, H et al. (1999) Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Biol Chem 380:679-87
Wex, T; Levy, B; Wex, H et al. (1999) Human cathepsins F and W: A new subgroup of cathepsins. Biochem Biophys Res Commun 259:401-7
Wex, T; Wex, H; Bromme, D (1999) The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene. Biol Chem 380:1439-42
Bromme, D; Li, Z; Barnes, M et al. (1999) Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. Biochemistry 38:2377-85
Moonga, B S; Dempster, D W (1998) Effects of peptide fragments of protein kinase C on isolated rat osteoclasts. Exp Physiol 83:717-25
Breuil, V; Cosman, F; Stein, L et al. (1998) Human osteoclast formation and activity in vitro: effects of alendronate. J Bone Miner Res 13:1721-9
Wang, B; Shi, G P; Yao, P M et al. (1998) Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem 273:32000-8

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