Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR041339-06
Application #
2080628
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1991-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Baron, R (1996) Molecular mechanisms of bone resorption: therapeutic implications. Rev Rhum Engl Ed 63:633-8
David, P; Horne, W C; Baron, R (1996) Vanadate inhibits vacuolar H(+)-ATPase-mediated proton transport in chicken kidney microsomes by an ADP-dependent mechanism. Biochim Biophys Acta 1280:155-60
David, P; Nguyen, H; Barbier, A et al. (1996) The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res 11:1498-507
Hernando, N; Bartkiewicz, M; Collin-Osdoby, P et al. (1995) Alternative splicing generates a second isoform of the catalytic A subunit of the vacuolar H(+)-ATPase. Proc Natl Acad Sci U S A 92:6087-91
Bartkiewicz, M; Hernando, N; Reddy, S V et al. (1995) Characterization of the osteoclast vacuolar H(+)-ATPase B-subunit. Gene 160:157-64
Ravesloot, J H; Eisen, T; Baron, R et al. (1995) Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts. J Gen Physiol 105:177-208
Baron, R (1995) Molecular mechanisms of bone resorption. An update. Acta Orthop Scand Suppl 266:66-70
David, P; Baron, R (1994) The catalytic cycle of the vacuolar H(+)-ATPase. Comparison of proton transport in kidney- and osteoclast-derived vesicles. J Biol Chem 269:30158-63
Chatterjee, D; Neff, L; Chakraborty, M et al. (1993) Sensitivity to nitrate and other oxyanions further distinguishes the vanadate-sensitive osteoclast proton pump from other vacuolar H(+)-ATPases. Biochemistry 32:2808-12
Chatterjee, D; Chakraborty, M; Leit, M et al. (1992) The osteoclast proton pump differs in its pharmacology and catalytic subunits from other vacuolar H(+)-ATPases. J Exp Biol 172:193-204

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