Abstract

The severe, disability and long term morbidity associated with fractures of the hip and spine have made osteoporosis one of the most significant musculoskeletal disorders. Despite significant advancements, successful preventive or treatment strategies remain unavailable. Paramount to progress in developing improved strategies is establishing the effect of tissue level alterations on the mechanical integrity of bone structure. The objectives of this research program is to investigate the contributions of bone tissue quality, quantity and organization to overall structural mechanical integrity. In addition, it is our purpose to evaluate the effects of age and sex on these inherent structure function relationships. Utilizing a combination of microscopic and macroscopic biomechanical tests and morphologic characterizations and analytical microstructural modeling we will address the following specific aims: 1. Experimentally determine the contribution of microstructural morphology to trabecular and cortical tissue properties. 2. Test for the effects of age and sex on the morphologic features of bone tissue and their consequential influence on functional properties. 3 .Tests for regional differences in tissue quality. 4. Determine the contribution of microscopic and continuum properties to whole bone mechanical integrity. 5. Develop a microstructurally based analytical modeling procedure to predict whole bone fractureability and parametrically evaluate failure criteria.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR041349-02
Application #
3161753
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Cody, D D; Hou, F J; Divine, G W et al. (2000) Femoral structure and stiffness in patients with femoral neck fracture. J Orthop Res 18:443-8
Cody, D D; Gross, G J; Hou, F J et al. (1999) Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech 32:1013-20
Zysset, P K; Goulet, R W; Hollister, S J (1998) A global relationship between trabecular bone morphology and homogenized elastic properties. J Biomech Eng 120:640-6
Jepsen, K J; Schaffler, M B; Kuhn, J L et al. (1997) Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech 30:1141-7
Jepsen, K J; Goldstein, S A; Kuhn, J L et al. (1996) Type-I collagen mutation compromises the post-yield behavior of Mov13 long bone. J Orthop Res 14:493-9
Hollister, S J; Brennan, J M; Kikuchi, N (1994) A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress. J Biomech 27:433-44
Goldstein, S A; Goulet, R; McCubbrey, D (1993) Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. Calcif Tissue Int 53 Suppl 1:S127-32;discussion S132-3
Huiskes, R; Hollister, S J (1993) From structure to process, from organ to cell: recent developments of FE-analysis in orthopaedic biomechanics. J Biomech Eng 115:520-7