Our current understanding about the pathogenesis of osteoporosis is limited by a lack of information about the factors that determine the amount of bone gained during growth. Since the attainment of greater bone mass at skeletal maturity may reduce the risk of developing osteoporosis later in life, a better understanding of the determinants of bone density during growth in childhood and adolescence is required. Preliminary cross-sectional studies indicate that bone density increases dramatically during puberty both in boys and in girls and that the extent of this rise during late puberty is greater in blacks than in whites. However, the factors responsible for increases in bone density during adolescence and the mechanisms which account for the development of racial differences in bone mass at this time in life remain uncertain. Specifically, the role of alterations in the serum levels of several important modifiers of bone cell metabolism during puberty, such as sex steroids and calcium-regulating hormones is unknown; the possibility that variations in the response of bone at the tissue level to these important regulators of bone metabolism also wan-ants further investigation. It is the purpose of the current proposal to examine more closely the roles of sex steroids and calcium regulating hormones as determinants of the normal pubertal increase in bone density in growing black and white children. The following objectives are delineated: 1. To characterize the changes in vertebral bone density of cancellous and cortical bone density at each stage of sexual development in black and white males and females. 2 .To determine the relationship between increases in bone density during-puberty and the serum levels of sex steroids and calcium regulating hormones. 3 . To determine whether prepubertal measurements of vertebral bone density predict bone density at skeletal maturity. 4. To compare both the response of bone and the change in growth hormone secretion in black and white children after estrogen administration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR041853-03
Application #
2081048
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1995-08-01
Budget End
1996-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
094878337
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Gilsanz, Vicente; Perez, Francisco J; Campbell, Patricia P et al. (2009) Quantitative CT reference values for vertebral trabecular bone density in children and young adults. Radiology 250:222-7
Di Iorgi, N; Mittelman, S D; Gilsanz, V (2008) Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults. Int J Obes (Lond) :
Wren, Tishya A L; Liu, Xiaodong; Pitukcheewanont, Pisit et al. (2005) Bone densitometry in pediatric populations: discrepancies in the diagnosis of osteoporosis by DXA and CT. J Pediatr 146:776-9
Pitukcheewanont, Pisit; Safani, David; Church, Joseph et al. (2005) Bone measures in HIV-1 infected children and adolescents: disparity between quantitative computed tomography and dual-energy X-ray absorptiometry measurements. Osteoporos Int 16:1393-6
Arfai, Kiumars; Pitukcheewanont, Pisit D; Goran, Michael I et al. (2002) Bone, muscle, and fat: sex-related differences in prepubertal children. Radiology 224:338-44
Skaggs, D L; Loro, M L; Pitukcheewanont, P et al. (2001) Increased body weight and decreased radial cross-sectional dimensions in girls with forearm fractures. J Bone Miner Res 16:1337-42
Loro, M L; Sayre, J; Roe, T F et al. (2000) Early identification of children predisposed to low peak bone mass and osteoporosis later in life. J Clin Endocrinol Metab 85:3908-18
Sainz, J; Van Tornout, J M; Sayre, J et al. (1999) Association of collagen type 1 alpha1 gene polymorphism with bone density in early childhood. J Clin Endocrinol Metab 84:853-5
Gilsanz, V (1998) Bone density in children: a review of the available techniques and indications. Eur J Radiol 26:177-82
Gilsanz, V; Skaggs, D L; Kovanlikaya, A et al. (1998) Differential effect of race on the axial and appendicular skeletons of children. J Clin Endocrinol Metab 83:1420-7

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