IL-4 - Immune Regulator of Skeletal Metabolism

Ross, F. Patrick

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR042356-03
• Application #: 2081542
• Study Section: Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
• Project Start: 1993-05-01
• Project End: 1997-04-30
• Budget Start: 1995-05-01
• Budget End: 1997-04-30
• Support Year: 3
• Fiscal Year: 1995

Institution

• Name: Barnes-Jewish Hospital
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63110

Publications

McHugh, K P; Kitazawa, S; Teitelbaum, S L et al. (2001) Cloning and characterization of the murine beta(3) integrin gene promoter: identification of an interleukin-4 responsive element and regulation by STAT-6. J Cell Biochem 81:320-32

Lacey, D L; Erdmann, J M; Teitelbaum, S L et al. (1995) Interleukin 4, interferon-gamma, and prostaglandin E impact the osteoclastic cell-forming potential of murine bone marrow macrophages. Endocrinology 136:2367-76

Gibbons, R; Ross, F P; Perkins, S L et al. (1994) Interleukin-4 enhances murine bone marrow macrophage M-CSF receptor expression by a posttranscriptional mechanism. Lymphokine Cytokine Res 13:85-92

Lacey, D L; Erdmann, J M; Shima, M et al. (1994) Interleukin 4 enhances osteoblast macrophage colony-stimulating factor, but not interleukin 6, production. Calcif Tissue Int 55:21-8

Bizzarri, C; Shioi, A; Teitelbaum, S L et al. (1994) Interleukin-4 inhibits bone resorption and acutely increases cytosolic Ca2+ in murine osteoclasts. J Biol Chem 269:13817-24

Lacey, D L; Erdmann, J M; Tan, H L (1994) Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages. J Cell Biochem 54:365-71