Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR042506-01A2
Application #
2081819
Study Section
Special Emphasis Panel (ZRG4-GMA-2 (01))
Project Start
1996-02-25
Project End
1998-11-30
Budget Start
1996-02-25
Budget End
1996-11-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Chen, P P; Wu, M; Hahn, B H (2010) Some antiphospholipid antibodies bind to various serine proteases in hemostasis and tip the balance toward hypercoagulant states. Lupus 19:365-9
Yang, Yao-Hsu; Chien, Daniel; Wu, Meifang et al. (2009) Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin. J Immunol 182:1674-80
Ede, Kaleo; Hwang, Kwan-Ki; Wu, Chen-Ching et al. (2009) Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice. Arthritis Rheum 60:3108-17
Pierangeli, Silvia S; Chen, Pojen P; Raschi, Elena et al. (2008) Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost 34:236-50
Chen, P P; Yang, C D; Ede, K et al. (2008) Some antiphospholipid antibodies bind to hemostasis and fibrinolysis proteases and promote thrombosis. Lupus 17:916-21
Lin, Wei-Shiang; Chen, Pei-Chih; Yang, Cheng-De et al. (2007) Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 56:1638-47
Chen, Xiao-Xiang; Gu, Yue-Ying; Li, Shu-Jie et al. (2007) Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice. J Immunol 178:5351-6
Vega-Ostertag, Mariano; Liu, Xiaowei; Kwan-Ki, Hwang et al. (2006) A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells. Br J Haematol 135:214-9
Yang, Yao-Hsu; Hwang, Kwan-Ki; FitzGerald, John et al. (2006) Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin. J Immunol 177:8219-25
Lu, Cai-Sheng; Horizon, Arash A; Hwang, Kwan-Ki et al. (2005) Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 52:4018-27

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