Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042563-03
Application #
2081919
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1993-12-20
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Pathology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
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Morel, L; Mohan, C; Yu, Y et al. (1999) Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 10:176-81
Sobel, E S; Mohan, C; Morel, L et al. (1999) Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells. J Immunol 162:2415-21
Mohan, C; Morel, L; Yang, P et al. (1998) Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice. Arthritis Rheum 41:1652-62
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Mohan, C; Morel, L; Yang, P et al. (1997) Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159:454-65
Morel, L; Yu, Y; Blenman, K R et al. (1996) Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7:335-9
Vyse, T J; Morel, L; Tanner, F J et al. (1996) Backcross analysis of genes linked to autoantibody production in New Zealand White mice. J Immunol 157:2719-27
Wu, J; Longmate, J A; Adamus, G et al. (1996) Interval mapping of quantitative trait loci controlling humoral immunity to exogenous antigens: evidence that non-MHC immune response genes may also influence susceptibility to autoimmunity. J Immunol 157:2498-505