Abstract

The purpose of this project is to utilize a large well established cohort to determine whether there is an association between immune abnormalities, silicone implants and connective tissue disorders. The frequency of autoantibodies in women who have breast implants and a connective tissue disease (CTD) as defined by ACR criteria will be determined. Control groups will include: 1) women with breast implants and CTD complaints who do not meet criteria; 2) women with breast implants with no CTD complaints; 3) women with breast implants with no CTD complaints that have capsular fibrosis; 4) women with CTD without breast implants; 5) women with CTD complaints but without breast implants; and 6) women with diabetes who take insulin injections without CTD complaints and without breast implants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042630-03
Application #
2082000
Study Section
Experimental Immunology Study Section (EI)
Project Start
1993-09-01
Project End
1998-08-31
Budget Start
1995-09-01
Budget End
1998-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Goldstein, Barbara L; Chibnik, Lori B; Karlson, Elizabeth W et al. (2012) Epstein-Barr virus serologic abnormalities and risk of rheumatoid arthritis among women. Autoimmunity 45:161-8
Arkema, Elizabeth V; Karlson, Elizabeth W; Costenbader, Karen H (2010) A prospective study of periodontal disease and risk of rheumatoid arthritis. J Rheumatol 37:1800-4
Costenbader, Karen H; Kang, Jae Hee; Karlson, Elizabeth W (2010) Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women. Am J Epidemiol 172:205-16
Costenbader, Karen H; Chang, Shun-Chiao; Laden, Francine et al. (2008) Geographic variation in rheumatoid arthritis incidence among women in the United States. Arch Intern Med 168:1664-70
Costenbader, K H; Feskanich, D; Holmes, M et al. (2008) Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann Rheum Dis 67:530-5
Benito-Garcia, Elizabeth; Feskanich, Diane; Hu, Frank B et al. (2007) Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study. Arthritis Res Ther 9:R16
Costenbader, Karen H; Feskanich, Diane; Mandl, Lisa A et al. (2006) Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 119:503.e1-9
Karlson, E W; Costenbader, K H; McAlindon, T E et al. (2005) High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women. Lupus 14:832-6
Karlson, Elizabeth W; Mandl, Lisa A; Aweh, Gideon N et al. (2003) Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors. Am J Med 114:93-8
Karlson, Elizabeth W; Mandl, Lisa A; Aweh, Gideon N et al. (2003) Coffee consumption and risk of rheumatoid arthritis. Arthritis Rheum 48:3055-60

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