Osteoporosis Approach Based on Bone Resorption Blockade

Rosenblatt, Michael

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR042833-02
• Application #: 2082323
• Study Section: Special Emphasis Panel (ZRG4-ORTH (01))
• Project Start: 1995-04-01
• Project End: 1999-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Beth Israel Deaconess Medical Center
• DUNS #: 076593722
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02215

Publications

Piserchio, Andrea; Han, Yinglin; Chorev, Michael et al. (2002) Structural characterization of a cyclic dipeptidomimetic: the effect of ring size on a 1,2,5-trisubstituted-3-oxo-1,4-diazepine system. Biopolymers 64:16-25

Yahalom, Dror; Wittelsberger, Angela; Mierke, Dale F et al. (2002) Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking study. Biochemistry 41:8321-31

Scheibler, L; Mierke, D F; Bitan, G et al. (2001) Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry 40:15117-26

Bitan, G; Scheibler, L; Teng, H et al. (2000) Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction. J Pept Res 55:181-94

Bitan, G; Scheibler, L; Mierke, D F et al. (2000) Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry 39:11014-23

Bitan, G; Scheibler, L; Greenberg, Z et al. (1999) Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking. Biochemistry 38:3414-20

Greenberg, Z; Stoch, S A; Traianedes, K et al. (1999) Covalent immobilization of recombinant human alphavbeta3 integrin on a solid support with retention of functionality. Anal Biochem 266:153-64