Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR043969-02
Application #
2083715
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43205
Yang, Yan; Chung, Erwin K; Zhou, Bi et al. (2004) The intricate role of complement component C4 in human systemic lupus erythematosus. Curr Dir Autoimmun 7:98-132
Yu, C Yung; Chung, Erwin K; Yang, Yan et al. (2003) Dancing with complement C4 and the RP-C4-CYP21-TNX (RCCX) modules of the major histocompatibility complex. Prog Nucleic Acid Res Mol Biol 75:217-92
Yang, Yan; Chung, Erwin K; Zhou, Bi et al. (2003) Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index. J Immunol 171:2734-45
Chung, Erwin K; Yang, Yan; Rennebohm, Robert M et al. (2002) Genetic sophistication of human complement components C4A and C4B and RP-C4-CYP21-TNX (RCCX) modules in the major histocompatibility complex. Am J Hum Genet 71:823-37
Rupert, Kristi L; Moulds, Joann M; Yang, Yan et al. (2002) The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes. J Immunol 169:1570-8
Chung, Erwin K; Yang, Yan; Rupert, Kristi L et al. (2002) Determining the one, two, three, or four long and short loci of human complement C4 in a major histocompatibility complex haplotype encoding C4A or C4B proteins. Am J Hum Genet 71:810-22
Blanchong, C A; Chung, E K; Rupert, K L et al. (2001) Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4. Int Immunopharmacol 1:365-92
Martinez, O P; Longman-Jacobsen, N; Davies, R et al. (2001) Genetics of human complement component C4 and evolution the central MHC. Front Biosci 6:D904-13
Yang, Z; Qu, X; Yu, C Y (2001) Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region. Front Biosci 6:D927-35
Yang, Z; Yu, C Y (2000) Organizations and gene duplications of the human and mouse MHC complement gene clusters. Exp Clin Immunogenet 17:17-Jan

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