This grant focuses on individual differences in the stress response as significant factors determining who develops a chronic pain syndrome characterized by widespread pain, and who is unable to recover from it. Maladaptive responses to pain and withdrawal from positive social interactions are studied as key factors that underlie the affective distress and persistence of fibromyalgia symptoms. To test this model three well established methods of inquiry are used: 1. Field assessments of responses to stress, developed in prior research on arthritis patients, and 2. Laboratory tests of stress reactivity under controlled experimental conditions. 3. Longitudinal follow-up of patient status 2 years after pre-tests. Two groups of Osteoarthritis participants are studied: (1) 150 OA participants who meet criteria for Fibromyalgia (FM), and (2) 200 participants with osteoarthritis (OA) who report levels of pain comparable to the FM group, but who do not display the classic tender point symptoms found among those with FM. Longitudinal assessments on all subjects as well as thorough initial testing will permit three types of comparisons. 1.The examination of case-control differences between groups of FM respondents and those with OA only. 2.The examination of variables predictive of recovery among those with FM. 3. The examination of those factors predictive of the onset of widespread pain among the OA sample that displayed only regional pain at the initial assessment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR046034-01A2
Application #
6332028
Study Section
Special Emphasis Panel (ZRG1-RPHB-3 (01))
Program Officer
Ader, Deborah N
Project Start
2001-05-08
Project End
2006-06-30
Budget Start
2001-05-08
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$474,393
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
188435911
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Sturgeon, John A; Zautra, Alex J; Arewasikporn, Anne (2014) A multilevel structural equation modeling analysis of vulnerabilities and resilience resources influencing affective adaptation to chronic pain. Pain 155:292-8
Sturgeon, John A; Yeung, Ellen WanHeung; Zautra, Alex J (2014) Respiratory sinus arrhythmia: a marker of resilience to pain induction. Int J Behav Med 21:961-5
Davis, Mary C; Thummala, Kirti; Zautra, Alex J (2014) Stress-related clinical pain and mood in women with chronic pain: moderating effects of depression and positive mood induction. Ann Behav Med 48:61-70
Taylor, Shannon Stark; Davis, Mary C; Zautra, Alex J (2013) Relationship status and quality moderate daily pain-related changes in physical disability, affect, and cognitions in women with chronic pain. Pain 154:147-53
Kratz, Anna L; Davis, Mary C; Zautra, Alex J (2012) Attachment predicts daily catastrophizing and social coping in women with pain. Health Psychol 31:278-285
Finan, Patrick H; Zautra, Alex J; Davis, Mary C et al. (2011) COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain 152:300-7
Rios, Rebeca; Zautra, Alex J (2011) Socioeconomic disparities in pain: the role of economic hardship and daily financial worry. Health Psychol 30:58-66
Finan, Patrick H; Zautra, Alex J; Davis, Mary C et al. (2010) Genetic influences on the dynamics of pain and affect in fibromyalgia. Health Psychol 29:134-42
Nicolson, Nancy A; Davis, Mary C; Kruszewski, Denise et al. (2010) Childhood maltreatment and diurnal cortisol patterns in women with chronic pain. Psychosom Med 72:471-80
Finan, Patrick H; Zautra, Alex J; Davis, Mary C (2009) Daily affect relations in fibromyalgia patients reveal positive affective disturbance. Psychosom Med 71:474-82

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