- The distinct expression patterns of many members of the phylogenetically conserved homeobox (""""""""HOX"""""""") gene family in both developing and adult skin implicate this group of controller genes in patterning and regenerative processes of the skin. The principal investigator has preliminary data that transgenic mice over-expressing Hoxc13 (GC13 mice) in pre- and postnatal skin exhibit hyperproliferation of follicular and epidermal keratinocytes. These mice exhibit alopecia and a progressive skin defect resembling ichthyosis. This animal model will be used to define the molecular mechanisms underlying these abnormalities, by studying expression of Hoxc13 and its neighbor Hoxc13, screening for differentially expressed mRNAs in skin of normal versus Hoxc13-mutant mouse skin, comparison of Hox12 knockout versus dominant gain-of-function mice, and transcriptional regulation of Hoxc13 and Hoxc12.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR047204-01
Application #
6191315
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Moshell, Alan N
Project Start
2000-08-10
Project End
2004-07-31
Budget Start
2000-08-10
Budget End
2001-07-31
Support Year
1
Fiscal Year
2000
Total Cost
$268,840
Indirect Cost
Name
Medical University of South Carolina
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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Potter, Christopher S; Pruett, Nathanael D; Kern, Michael J et al. (2011) The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol 131:828-37
Bazzi, Hisham; Demehri, Shadmehr; Potter, Christopher S et al. (2009) Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation 78:292-300
Rice, Robert H; Rocke, David M; Tsai, Hua-Sheng et al. (2009) Distinguishing mouse strains by proteomic analysis of pelage hair. J Invest Dermatol 129:2120-5

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