Osteoporosis is a condition characterized by a reduction in the bone mineral density, impaired bone quality and frequent occurrence of fractures resulting from minor trauma. Current assessment of osteoporotic fracture risk is based on bone densitometry techniques that do not entirely predict fracture risk or the impact of a particular intervention. Bone quality encompasses bone geometry and macro-architecture, trabecular bone structure, matrix calcification, bone turnover. The quantitative analysis of bone structure and the elucidation of relationships between structural parameters and bone strength may have a major impact upon the prediction of fracture risk and evaluation of different therapies. In this application, we are proposing to extend our previous work and make use of recent advances in hardware and software, to obtain three-dimensional (3-D) magnetic resonance (MR) images with resolutions of approximately 100x 100x300 microns so as to accurately quantify the 3-D architecture of the trabecular bone network in the radius, calcaneus and proximal femur, and perform a rigorous evaluation of the impact of these data on the pathophysiological changes in skeletal bone and trabecular micro-architecture in aging, osteoporosis and fracture susceptibility.
The specific aims of this study will be to establish non-invasive, reproducible imaging surrogates that can be used to assess bone quality in vivo. MR image derived parameters of trabecular micro-architecture at the different measurement sites will be related to age, menopause status and osteoporotic status in a cohort of 250 subjects. The primary question that will be addressed is whether MR assessment of trabecular micro-architecture at the radius, calcaneus and proximal femur, combined with bone mineral density, provide a means to explain the discrepancy between bone mineral density and fracture occurrence. We will assess whether using MR derived measures of trabecular bone at the different skeletal sites show site specific differences, relationship between structure and bone mineral density at these sites, and whether these measures may be used to complement bone mineral density measurements in the study of osteoporosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR049701-01
Application #
6589814
Study Section
Special Emphasis Panel (ZAR1-TAS-B (O3))
Program Officer
Lester, Gayle E
Project Start
2002-09-30
Project End
2007-08-31
Budget Start
2002-09-30
Budget End
2003-08-31
Support Year
1
Fiscal Year
2002
Total Cost
$351,864
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Krug, Roland; Larson, Peder Eric Zufall; Wang, Chunsheng et al. (2011) Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging 34:691-5
Issever, Ahi Sema; Link, Thomas M; Newitt, David et al. (2010) Interrelationships between 3-T-MRI-derived cortical and trabecular bone structure parameters and quantitative-computed-tomography-derivedbone mineral density. Magn Reson Imaging 28:1299-305
Krug, R; Carballido-Gamio, J; Burghardt, A J et al. (2008) Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int 19:653-61
Krug, Roland; Carballido-Gamio, Julio; Banerjee, Suchandrima et al. (2008) In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging 27:854-9
Banerjee, Suchandrima; Krug, Roland; Carballido-Gamio, Julio et al. (2008) Rapid in vivo musculoskeletal MR with parallel imaging at 7T. Magn Reson Med 59:655-60
Krug, Roland; Carballido-Gamio, Julio; Banerjee, Suchandrima et al. (2007) In vivo bone and cartilage MRI using fully-balanced steady-state free-precession at 7 tesla. Magn Reson Med 58:1294-8
Blumenfeld, Janet; Carballido-Gamio, Julio; Krug, Roland et al. (2007) Automatic prospective registration of high-resolution trabecular bone images of the tibia. Ann Biomed Eng 35:1924-31
Krug, Roland; Carballido-Gamio, Julio; Burghardt, Andrew J et al. (2007) Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging 25:392-8
Krug, R; Han, E T; Banerjee, S et al. (2006) Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med 56:1033-40
Carballido-Gamio, Julio; Phan, Catherine; Link, Thomas M et al. (2006) Characterization of trabecular bone structure from high-resolution magnetic resonance images using fuzzy logic. Magn Reson Imaging 24:1023-9