Osteoarthritis (OA) of the knee occurs in a substantial portion of the population over the age of fifty. The substantial variation in the rate of initiation and progression of the disease can be influenced by normal variation in the in vivo function of the knee during locomotion. Yet the specific functional measures (kinematic and load) that produce adaptive vs. degenerative to the articular cartilage at the knee during ambulation are not well understood. The long-term goal of this study is to test a specific mechanism that relates in vivo knee function (kinematics and loading during locomotion) to the progression of osteoarthritis (OA) at the knee. As an initial step toward this goal, this project will test the overall hypothesis that regional variations in knee cartilage thickness (in an asymptomatic population with no history of soft tissue injury at the knee) are related to specific kinematic and loading characteristic at the knee during walking. The following Specific Aims will be addressed: (1) to evaluate the relationship between loading at the knee during locomotion and regional variations in cartilage thickness; (2) to evaluate the relationship between a positional offset at the knee during locomotion and regional variations in cartilage thickness; and (3) to evaluate the relationship between motion at the knee during locomotion and regional variations in cartilage thickness. The methods to test the hypotheses will combine state-of-the-art methods for the analysis of human movement, and magnetic resonance imaging (MRI) techniques to quantify femoral and tibial cartilage thickness. A population of asymptomatic subjects (stratified by ages between 20 and 70 years) will be tested studied using a cross-sectional study design. The results of this study will address important unanswered questions on the kinematic and morphological factors that can influence the degradation of the articular cartilage. Information on the relative importance of loading and motion during walking will provide fundamental new information that can ultimately be applied to prevention and treatment of knee OA. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR049792-03
Application #
6997794
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Program Officer
Panagis, James S
Project Start
2004-03-16
Project End
2008-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$326,913
Indirect Cost
Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Koo, Seungbum; Rylander, Jonathan H; Andriacchi, Thomas P (2011) Knee joint kinematics during walking influences the spatial cartilage thickness distribution in the knee. J Biomech 44:1405-9
Dowling, Ariel V; Fisher, David S; Andriacchi, Thomas P (2010) Gait modification via verbal instruction and an active feedback system to reduce peak knee adduction moment. J Biomech Eng 132:071007
Koo, Seungbum; Giori, Nicholas J; Gold, Garry E et al. (2009) Accuracy of 3D cartilage models generated from MR images is dependent on cartilage thickness: laser scanner based validation of in vivo cartilage. J Biomech Eng 131:121004
Bevill, S L; Briant, P L; Levenston, M E et al. (2009) Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression. Osteoarthritis Cartilage 17:980-7
Koo, Seungbum; Andriacchi, Thomas P (2008) The knee joint center of rotation is predominantly on the lateral side during normal walking. J Biomech 41:1269-73
Koo, Seungbum; Andriacchi, Thomas P (2007) A comparison of the influence of global functional loads vs. local contact anatomy on articular cartilage thickness at the knee. J Biomech 40:2961-6
Andriacchi, Thomas P; Mundermann, Annegret (2006) The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr Opin Rheumatol 18:514-8
Kornaat, Peter R; Koo, Seungbum; Andriacchi, Thomas P et al. (2006) Comparison of quantitative cartilage measurements acquired on two 3.0T MRI systems from different manufacturers. J Magn Reson Imaging 23:770-3
Andriacchi, Thomas P; Briant, Paul L; Bevill, Scott L et al. (2006) Rotational changes at the knee after ACL injury cause cartilage thinning. Clin Orthop Relat Res 442:39-44
Koo, S; Gold, G E; Andriacchi, T P (2005) Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy. Osteoarthritis Cartilage 13:782-9

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