It is generally thought that muscle excitability is controlled by only a few types of ion channels. We propose this understanding is incomplete and misses important ion channel types that regulate excitability during repetitive firing, but do not participate in a major way in firing of single action potentials. Since these currents are small, they are hard to identify and have been missed. In this proposal we will test the hypothesis that a novel current we discovered in muscle during studies of myotonia congenita and hyperkalemic periodic paralysis also plays a central role in triggering attacks of weakness in hypokalemic periodic paralysis. If successful this work has the potential to lead to improved therapy for patients.

Public Health Relevance

Patients with muscle diseases known as channelopathies suffer from muscle stiffness and bouts of weakness. In this proposal we explore development of novel therapy for weakness in patients with the muscle channelopathy hypokalemic periodic paralysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR074985-01S1
Application #
9926525
Study Section
Program Officer
Cheever, Thomas
Project Start
2019-07-01
Project End
2022-03-31
Budget Start
2019-07-01
Budget End
2020-03-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Wright State University
Department
Type
DUNS #
047814256
City
Dayton
State
OH
Country
United States
Zip Code
45435