A thorough understanding of cells and molecules that regulate tissue repair and fibrosis is essential for the generation of tissue-specific regenerative therapies to effectively treat human disease. Since the manner in which adipocytes function during skin wound healing is largely unknown, we will define how these major but poorly understood cells function during skin wound healing. Our work will improve our understanding of the cells and molecules that control basic skin regeneration, how adipocytes function in this process, and will have global relevance for other tissues that contain adipocytes.
