Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA012623-23
Application #
2086077
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1977-08-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Hawaii
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822

  Publications

Magarvey, Nathan A; Beck, Zachary Q; Golakoti, Trimurtulu et al. (2006) Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. ACS Chem Biol 1:766-79
Liang, Jian; Moore, Richard E; Moher, Eric D et al. (2005) Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors. Invest New Drugs 23:213-24
Chaganty, Sreedhara; Golakoti, Trimurtulu; Heltzel, Carl et al. (2004) Isolation and structure determination of cryptophycins 38, 326, and 327 from the terrestrial cyanobacterium Nostoc sp. GSV 224. J Nat Prod 67:1403-6
Becker, Julia E; Moore, Richard E; Moore, Bradley S (2004) Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. Gene 325:35-42
Williams, Philip G; Yoshida, Wesley Y; Moore, Richard E et al. (2004) Micromide and guamamide: cytotoxic alkaloids from a species of the marine cyanobacterium Symploca. J Nat Prod 67:49-53
Williams, Philip G; Moore, Richard E; Paul, Valerie J (2003) Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin J Nat Prod 66:1356-63
Williams, Philip G; Yoshida, Wesley Y; Moore, Richard E et al. (2003) Tasipeptins A and B: new cytotoxic depsipeptides from the marine cyanobacterium Symploca sp. J Nat Prod 66:620-4
Williams, Philip G; Yoshida, Wesley Y; Moore, Richard E et al. (2003) The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp. J Nat Prod 66:1006-9
Williams, Philip G; Yoshida, Wesley Y; Quon, Michael K et al. (2003) Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp. J Nat Prod 66:651-4
Luesch, Hendrik; Hoffmann, Dietmar; Hevel, Joan M et al. (2003) Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities. J Org Chem 68:83-91

Showing the most recent 10 out of 42 publications