Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA015988-18
Application #
2086384
Study Section
Experimental Immunology Study Section (EI)
Project Start
1978-05-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
18
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Glickstein, L; Macphail, S; Stutman, O (1996) Uncoupling IL-2 production from apoptosis and TNF production by changing the signal through the TCR. J Immunol 156:2062-7
Shih, S C; Stutman, O (1996) Cell cycle-dependent tumor necrosis factor apoptosis. Cancer Res 56:1591-8
Macphail, S; Stutman, O (1993) H-2 I-E molecules isolated from Mls1a stimulatory cells do not activate Mls1a-responsive T cells but do present exogenous staphylococcal enterotoxins. Eur J Immunol 23:90-5
Hernandez-Caselles, T; Stutman, O (1993) Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. J Immunol 151:3999-4012
Lattime, E C; Stutman, O (1992) WEHI-164 clone 2F: in vitro antitumor effects of tumor necrosis factor and gamma-interferon. Nat Immun 11:34-45
Lattime, E C; Stutman, O (1991) Antitumor immune surveillance by tumor necrosis factor producing cells. Immunol Res 10:104-13
Lattime, E C; Stutman, O (1989) Tumor growth in vivo selects for resistance to tumor necrosis factor. J Immunol 143:4317-23
Macphail, S; Stutman, O (1988) Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A 85:5205-9
Lattime, E C; Stoppacciaro, A; Khan, A et al. (1988) Human natural cytotoxic activity mediated by tumor necrosis factor: regulation by interleukin-2. J Natl Cancer Inst 80:1035-8
Lattime, E C; Stoppacciaro, A; Stutman, O (1988) Limiting dilution analysis of TNF producing cells in C3H/HeJ mice. J Immunol 141:3422-8

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