Abstract

The objective of these studies is to elucidate the mechanisms by which hormones regulate mammary gland development and milk protein gene expression, and to determine how these regulatory mechanisms have deviated in breast cancer.
Aim 1 is to study the regulation and function of different C/EBP isoforms during mammary gland development and carcinogenesis.
Aim 2 will attempt to elucidate the function of different Stat5 isoforms during mammary gland development and carcinogenesis.
Aim 3 will characterize specific NF1 isoforms expressed in the mammary gland.
In Aim 4, mechanisms of post transcriptional regulation of milk protein gene expression will be examined.
In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA016303-23
Application #
2653944
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Longfellow, David G
Project Start
1978-08-01
Project End
2002-01-31
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
23
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Lu, Yang; Cao, Jin; Napoli, Marco et al. (2018) miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution. Stem Cells 36:1875-1889
Janghorban, Mahnaz; Xin, Li; Rosen, Jeffrey M et al. (2018) Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target? Front Immunol 9:1649
Nguyen, Tuan M; Kabotyanski, Elena B; Dou, Yongchao et al. (2018) FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res 78:4229-4240
Zhang, Peng; He, Dandan; Xu, Yi et al. (2017) Genome-wide identification and differential analysis of translational initiation. Nat Commun 8:1749
Sreekumar, Amulya; Toneff, Michael J; Toh, Eajer et al. (2017) WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell 43:436-448.e6
Roarty, K; Pfefferle, A D; Creighton, C J et al. (2017) Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene 36:5958-5968
Welte, Thomas; Zhang, Xiang H-F; Rosen, Jeffrey M (2017) Repurposing Antiestrogens for Tumor Immunotherapy. Cancer Discov 7:17-19
Zhang, Mei; Lee, Adrian V; Rosen, Jeffrey M (2017) The Cellular Origin and Evolution of Breast Cancer. Cold Spring Harb Perspect Med 7:
Shore, Amy N; Chang, Chi-Hsuan; Kwon, Oh-Joon et al. (2016) PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol 409:202-217
Welte, Thomas; Kim, Ik Sun; Tian, Lin et al. (2016) Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol 18:632-44

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