One variant of the antibody-dependent kill is particularly pertinent to the immune-mediated destruction of tumors in vivo. Animals bearing tumors of quite large size (i.e., up to 10?9? cells) can be effectively destroyed by the systemic administration of antitumor antibodies (particularly of the IgG?2a? isotype). In three distinct models, we have found that the limiting variables in such destruction are the number of macrophages within the tumor bed activated for the slow variant of ADCC. One of these models is of particular interest because it involves the destruction of established syngeneic tumors invading the tissues. Studies over the coming years are aimed at understanding lysis in molecular terms, studying the cell biology that leads to effective recognition, and analyzing how we can regulate macrophage activation more appropriately to cause increased destruction of tumors in the tissues. (MB)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA016784-11
Application #
3164522
Study Section
Pathology A Study Section (PTHA)
Project Start
1978-05-01
Project End
1986-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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