Abstract

The need to define the events of tumor-host interactions in modern immunological terms is apparent. By using autochthonous and transplanted syngeneic tumors in mice, especially murine mammary tumor virus (MuMTV)-induced mammary adenocarcinomas, we will continue our studies on the immune response of the host against such tumors.
Our aims will include studies on the specific (and less-specific) cytotoxic T lymphocytes (CTL) induced by in vivo or in vitro immunization, as well as CTL lines. The properties of CTL effectors and of the components which regulate their function will be studied, with special emphasis on regulatory cells of the suppressor type. The main goal of these studies is to define a strategy, based on immunological intervention, which will affect behavior of transplanted mammary tumors and, more importantly, spontaneous mammary tumor development in the high-risk MuMTV-infected C3H/BiUmc (C3H) virgin females. This information may be relevant for planning similar immunological strategies for clinical use, especially those derived from the in vivo effects of CTL lines and of other T-cell lines with regulatory function, or from our models for abrogation of suppressor T cells in vivo. (TA)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA017818-12
Application #
3164800
Study Section
Immunobiology Study Section (IMB)
Project Start
1979-01-01
Project End
1989-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Macphail, S; Stutman, O (1989) Specific neonatal induction of functional tolerance to allogeneic Mls determinants occurs intrathymically and the tolerant state is Mls haplotype-specific. J Immunol 143:1795-800
Macphail, S; Stutman, O (1988) Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A 85:5205-9
Chan, M M; Hammerling, U; Stutman, O (1988) The Ly-10 antigen is a marker of mouse-activated T lymphocytes. Immunogenetics 28:425-32
Macphail, S; Stutman, O (1988) Mls allo-determinants are recognized in an MHC class II antigen-dependent but unrestricted fashion by a discrete set of T cells. J Immunogenet 15:87-99
Macphail, S; Stutman, O (1987) L3T4+ cytotoxic T lymphocytes specific for class I H-2 antigens are activated in primary mixed lymphocyte reactions. J Immunol 139:4007-15
Lattime, E C; Stutman, O (1986) L3T4+, B2A2+ thymocytes from infant mice produce IL 2 after interaction with accessory cells expressing self class II antigens. J Immunol 136:2741-6
Stutman, O (1986) Postthymic T-cell development. Immunol Rev 91:159-94
Macphail, S; Stutman, O (1986) H-2-linked genes determine the level of the primary in vitro anti-Mls response. Immunogenetics 24:139-45
Macphail, S; Stutman, O (1986) Heterogeneous cytotoxic cells that kill NC-sensitive WEHI-164 tumor cells are activated in allogeneic mixed lymphocyte reactions. Immunol Res 5:40-9
Ishizaka, S T; Carnaud, C; Stutman, O (1986) Differential susceptibility of cytotoxic and helper T cell precursors to neonatal tolerization to histocompatibility antigens. J Immunol 137:2093-9

Showing the most recent 10 out of 12 publications