Abstract

Our objectives are to extend our studies of the genetic control of the transformed and tumorigenic phenotypes in human cells. The characterization of human-associated antigen pp75 is currently underway. We have optimized the conditions for the stable integration of single copies of selectable genes into individual chromosomes on a random basis and are working to complete a human chromosomal library. (P)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA019401-10
Application #
3165151
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1976-06-30
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Liao, S-Y; Ivanov, S; Ivanova, A et al. (2003) Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. J Med Genet 40:257-61
Kaluz, Stefan; Kaluzova, Milota; Chrastina, Adrian et al. (2002) Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. Cancer Res 62:4469-77
Cheng, Yue; Chakrabarti, Rita; Garcia-Barcelo, Merce et al. (2002) Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-megabase region of chromosome band 11q13. Genes Chromosomes Cancer 34:97-103
Srivatsan, Eri S; Chakrabarti, Rita; Zainabadi, Kayvan et al. (2002) Localization of deletion to a 300 Kb interval of chromosome 11q13 in cervical cancer. Oncogene 21:5631-42
Ivanov, S; Liao, S Y; Ivanova, A et al. (2001) Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 158:905-19
Kong, X T; Gao, H; Stanbridge, E J (2001) Mechanisms of differential activation of target gene promoters by p53 hinge domain mutants with impaired apoptotic function. J Biol Chem 276:32990-3000
Kaluzova, M; Pastorekova, S; Svastova, E et al. (2001) Characterization of the MN/CA 9 promoter proximal region: a role for specificity protein (SP) and activator protein 1 (AP1) factors. Biochem J 359:669-77
Tsujimoto, H; Nishizuka, S; Redpath, L J et al. (2001) Examination of the oncogenic potential of H19 gene in HeLa x normal human fibroblast hybrid cells. Int J Oncol 19:89-95
Olive, P L; Aquino-Parsons, C; MacPhail, S H et al. (2001) Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer. Cancer Res 61:8924-9
Srivatsan, E S; Bengtsson, U; Manickam, P et al. (2000) Interstitial deletion of 11q13 sequences in HeLa cells. Genes Chromosomes Cancer 29:157-65

Showing the most recent 10 out of 58 publications