Human adenoviruses induce tumors in rodents in vivo and can also efficiently transform cells in vitro. For unexplained reasons the in vivo tumorigenic potential of different adenovirus serotypes varies over a broad range, from nontumorigenic to highly tumorigenic. The role of specific adenovirus genes in tumorigenicity will be studied by analysis of tumorigenic potential of viable recombinant viruses constructed from highly oncogenic and nonongocenic adenovirus serotypes, cells transformed by such viruses and cells transformed with cloned fragments of adenovirus DNA. The effects of specific gene products of highly oncogenic and nononcogenic adenoviruses expressed in transformed cells on interaction with host defense mechanisms, particularly cellular immunity, both natural and induced, will be analyzed. Attention also will be paid to modulation of phenotype of transformed cells during tumor development. Relationship of tumorigenic potential of transformed cells and specific parameters of their interaction with extracellular matrix will also be studied. The studies will provide clues for elucidating the mechanisms responsible for the great differences in oncogenic potential of different adenovirus serotypes in vivo.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA021196-09A1
Application #
3165481
Study Section
Virology Study Section (VR)
Project Start
1977-09-30
Project End
1991-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
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