Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA022555-11S1
Application #
3165847
Study Section
Experimental Virology Study Section (EVR)
Project Start
1978-01-01
Project End
1989-07-31
Budget Start
1988-01-01
Budget End
1989-07-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Lednicky, J A; Jafar, S; Wong, C et al. (1997) High-fidelity PCR amplification of infectious copies of the complete simian virus 40 genome from plasmids and virus-infected cell lysates. Gene 184:189-95
Lednicky, J A; Butel, J S (1997) Tissue culture adaptation of natural isolates of simian virus 40: changes occur in viral regulatory region but not in carboxy-terminal domain of large T-antigen. J Gen Virol 78 ( Pt 7):1697-705
Lednicky, J A; Butel, J S (1997) A coupled PCR and restriction digest method for the detection and analysis of the SV40 regulatory region in infected-cell lysates and clinical samples. J Virol Methods 64:1-9
Lednicky, J A; Stewart, A R; Jenkins 3rd, J J et al. (1997) SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes. Int J Cancer 72:791-800
Stewart, A R; Lednicky, J A; Benzick, U S et al. (1996) Identification of a variable region at the carboxy terminus of SV40 large T-antigen. Virology 221:355-61
Lednicky, J A; Garcea, R L; Bergsagel, D J et al. (1995) Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology 212:710-7
Lednicky, J A; Wong, C; Butel, J S (1995) Artificial modification of the viral regulatory region improves tissue culture growth of SV40 strain 776. Virus Res 35:143-53
Sawai, E T; Rasmussen, G; Butel, J S (1994) Construction of SV40 deletion mutants and delimitation of the binding domain for heat shock protein to the amino terminus of large T-antigen. Virus Res 31:367-78
Fromm, L; Shawlot, W; Gunning, K et al. (1994) The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell Biol 14:6743-54
Bergsagel, D J; Finegold, M J; Butel, J S et al. (1992) DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med 326:988-93

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