Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA026345-17A1
Application #
2087495
Study Section
Virology Study Section (VR)
Project Start
1979-07-01
Project End
2001-04-30
Budget Start
1996-07-20
Budget End
1997-04-30
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Uprichard, Susan L; Knipe, David M (2003) Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures. J Virol 77:7467-76
Taylor, Travis J; McNamee, Elizabeth E; Day, Cheryl et al. (2003) Herpes simplex virus replication compartments can form by coalescence of smaller compartments. Virology 309:232-47
Taylor, Travis J; Knipe, David M (2003) C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization. Virology 309:219-31
Zhou, Changhong; Knipe, David M (2002) Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme. J Virol 76:5893-904
Brockman, Mark A; Knipe, David M (2002) Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity. J Virol 76:3678-87
Da Costa, X J; Morrison, L A; Knipe, D M (2001) Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection. Virology 288:256-63
McNamee, E E; Taylor, T J; Knipe, D M (2000) A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: effects on DNA replication and late gene expression. J Virol 74:10122-31
Da Costa, X; Kramer, M F; Zhu, J et al. (2000) Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2. J Virol 74:7963-71
de Bruyn Kops, A; Uprichard, S L; Chen, M et al. (1998) Comparison of the intranuclear distributions of herpes simplex virus proteins involved in various viral functions. Virology 252:162-78
Uprichard, S L; Knipe, D M (1997) Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites. Virology 229:113-25

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