This proposal will investigate the molecular mechanisms used by the abl oncogene in its normal and abnormal growth regulation. Comparison of the structures, regulation, hematopoietic transformation activities, and tyrosine kinase enzymatic properties of the murine cellular, and viral forms of the abl gene as well as the translocation derived form of the abl gene found in Chronic Myelogenous Leukemia cells will be performed. Emphasis will be placed on establishing transformed cell models for murine stem cell populations under the regulation of abl or other oncogenes in concert with improved culture techniques. These studies should aid our understanding of the mechanisms of oncogenesis and hematopoietic development.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA027507-10
Application #
3167667
Study Section
Experimental Virology Study Section (EVR)
Project Start
1980-05-01
Project End
1991-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
10
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095