Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA027674-06S1
Application #
3167769
Study Section
Biochemistry Study Section (BIO)
Project Start
1980-03-01
Project End
1986-06-30
Budget Start
1985-03-01
Budget End
1986-06-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Bergh, S T; Evans, D R (1993) Subunit structure of a class A aspartate transcarbamoylase from Pseudomonas fluorescens. Proc Natl Acad Sci U S A 90:9818-22
Kim, H; Kelly, R E; Evans, D R (1992) The structural organization of the hamster multifunctional protein CAD. Controlled proteolysis, domains, and linkers. J Biol Chem 267:7177-84
Kim, H S; Lee, L; Evans, D R (1991) Identification of the ATP binding sites of the carbamyl phosphate synthetase domain of the Syrian hamster multifunctional protein CAD by affinity labeling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. Biochemistry 30:10322-9
Scully, J L; Evans, D R (1991) Comparative modeling of mammalian aspartate transcarbamylase. Proteins 9:191-206
Bein, K; Simmer, J P; Evans, D R (1991) Molecular cloning of a cDNA encoding the amino end of the mammalian multifunctional protein CAD and analysis of the 5'-flanking region of the CAD gene. J Biol Chem 266:3791-9
Chaparian, M G; Evans, D R (1991) The catalytic mechanism of the amidotransferase domain of the Syrian hamster multifunctional protein CAD. Evidence for a CAD-glutamyl covalent intermediate in the formation of carbamyl phosphate. J Biol Chem 266:3387-95
Simmer, J P; Kelly, R E; Rinker Jr, A G et al. (1990) Mammalian dihydroorotase: nucleotide sequence, peptide sequences, and evolution of the dihydroorotase domain of the multifunctional protein CAD. Proc Natl Acad Sci U S A 87:174-8
Simmer, J P; Kelly, R E; Rinker Jr, A G et al. (1990) Mammalian carbamyl phosphate synthetase (CPS). DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD. J Biol Chem 265:10395-402
Simmer, J P; Kelly, R E; Scully, J L et al. (1989) Mammalian aspartate transcarbamylase (ATCase): sequence of the ATCase domain and interdomain linker in the CAD multifunctional polypeptide and properties of the isolated domain. Proc Natl Acad Sci U S A 86:4382-6
Chaparian, M G; Evans, D R (1988) Intracellular location of the multidomain protein CAD in mammalian cells. FASEB J 2:2982-9

Showing the most recent 10 out of 13 publications